Newcastle-Ottawa analysis was done for selected articles quality assessment, bias in publication (if any) was estimated through Funnel plots and Egger’s test. PubMed (Medline), EMBASE, & Google Scholar databases were searched for eligible studies and pooled odds ratios (ORs) and 95% confidence intervals (CI) were calculated. This meta-analysis explores the precise relationship between CCND1 G870A polymorphism and OC risk. Several findings have reported that Cyclin D1 (CCND1) G870A Single nucleotide polymorphism is associated with oral cancer (OC) risk, but yielded inconsistent data across different studies.
Cyclin D1 is one such cell cycle regulatory gene.
Recently Cell cycle regulatory /Senescence genes have been associated with Gingivitis/ Periodontitis susceptibility. A high incidence of oral cancer has been reported in the case of chronic periodontitis. Strong association has been recently observed between periodontitis/gingivitis and Oral squamous cell carcinoma (OSCC).
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